8UGB
Cryo-EM structure of bovine phosphodiesterase 6 bound to udenafil
Summary for 8UGB
Entry DOI | 10.2210/pdb8ugb/pdb |
EMDB information | 42220 |
Descriptor | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ... (7 entities in total) |
Functional Keywords | phosphodiesterase, gpcr effector enzyme, signaling protein, inhibitor, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Bos taurus (cattle) More |
Total number of polymer chains | 4 |
Total formula weight | 219183.05 |
Authors | Aplin, C.,Cerione, R.A. (deposition date: 2023-10-05, release date: 2024-01-17, Last modification date: 2024-02-07) |
Primary citation | Aplin, C.,Cerione, R.A. Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6. J.Biol.Chem., 300:105608-105608, 2023 Cited by PubMed: 38159849DOI: 10.1016/j.jbc.2023.105608 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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