8UDZ
The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex
Summary for 8UDZ
Entry DOI | 10.2210/pdb8udz/pdb |
Descriptor | Transforming growth factor beta-1 proprotein, LTBP-49247 Fab Heavy Chain, LTBP-49247 Fab Light Chain, ... (6 entities in total) |
Functional Keywords | growth factor, antibody, fibrosis, tgfbeta, signaling protein, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 180965.25 |
Authors | Streich Jr., F.C.,Nicholls, S.B.,Boston, C.J.,Ramachandran, S. (deposition date: 2023-09-29, release date: 2024-07-17) |
Primary citation | Jackson, J.W.,Streich Jr., F.C.,Pal, A.,Coricor, G.,Boston, C.,Brueckner, C.T.,Canonico, K.,Chapron, C.,Cote, S.,Dagbay, K.B.,Danehy Jr., F.T.,Kavosi, M.,Kumar, S.,Lin, S.,Littlefield, C.,Looby, K.,Manohar, R.,Martin, C.J.,Wood, M.,Zawadzka, A.,Wawersik, S.,Nicholls, S.B.,Datta, A.,Buckler, A.,Schurpf, T.,Carven, G.J.,Qatanani, M.,Fogel, A.I. An antibody that inhibits TGF-beta 1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci.Signal., 17:eadn6052-eadn6052, 2024 Cited by PubMed: 38980922DOI: 10.1126/scisignal.adn6052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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