8UDZ
The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transforming growth factor beta-1 proprotein | polymer | 361 | 41221.0 | 2 | UniProt (P01137) Pfam (PF00688) Pfam (PF00019) In PDB | Homo sapiens (human) | |
2 | C, E | LTBP-49247 Fab Heavy Chain | polymer | 233 | 25100.3 | 2 | Homo sapiens | ||
3 | D, F | LTBP-49247 Fab Light Chain | polymer | 218 | 23484.6 | 2 | Homo sapiens | ||
4 | G | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
6 | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 390 (UniProt: P01137)
PDB | External Database | Details |
---|---|---|
Ser 33 | Cys 33 | engineered mutation |
Ala 278 | Arg 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 179612.0 | |
Branched | Number of molecules | 1 |
Total formula weight | 910.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 180965.2 |