8UDZ
The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transforming growth factor beta-1 proprotein | polymer | 361 | 41221.0 | 2 | UniProt (P01137) Pfam (PF00688) Pfam (PF00019) | Homo sapiens (human) | |
| 2 | C, E (C, E) | LTBP-49247 Fab Heavy Chain | polymer | 233 | 25100.3 | 2 | Homo sapiens | ||
| 3 | D, F (D, F) | LTBP-49247 Fab Light Chain | polymer | 218 | 23484.6 | 2 | Homo sapiens | ||
| 4 | G (G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 5 | H, I (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | J, K, L, M, N... (A, B, C, D, E...) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 390 (UniProt: P01137)
| PDB | External Database | Details |
|---|---|---|
| Ser 33 | Cys 33 | engineered mutation |
| Ala 278 | Arg 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 179612.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 180965.2 |
