8U27
Bcl-2-xL complexed with compound 35
Summary for 8U27
Entry DOI | 10.2210/pdb8u27/pdb |
NMR Information | BMRB: 52100 |
Descriptor | Apoptosis regulator Bcl-2, Bcl-2-like protein 1 chimera, propan-2-yl {4-[(5S)-1-(4-bromobenzoyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}carbamate (2 entities in total) |
Functional Keywords | autophagy, apoptosis, selective inhibition |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 21199.52 |
Authors | Rizo, J.,Pan, Y.-Z. (deposition date: 2023-09-05, release date: 2023-09-13, Last modification date: 2024-05-15) |
Primary citation | Pan, Y.Z.,Liang, Q.,Tomchick, D.R.,De Brabander, J.K.,Rizo, J. Structural insights for selective disruption of Beclin 1 binding to Bcl-2. Commun Biol, 6:1080-1080, 2023 Cited by PubMed: 37875561DOI: 10.1038/s42003-023-05467-w PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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