8TXG
Crystal structure of KRAS G12D in complex with GDP and compound 8
Summary for 8TXG
Entry DOI | 10.2210/pdb8txg/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | molecule, gtpase, kras, inhibitor, oncoprotein, oncoprotein-inhibitor complex, oncoprotein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20470.45 |
Authors | |
Primary citation | Cheng, H.,Li, P.,Chen, P.,Irimia, A.,Bae, J.H.,Brooun, A.,Fagan, P.,Lam, R.,Lin, B.,Zhang, J.,Zhan, X.,Wu, X.,Xie, N.,Chiang, G.,Shoemaker, R.,Vernier, J.M. Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors. Acs Med.Chem.Lett., 14:1351-1357, 2023 Cited by PubMed: 37849557DOI: 10.1021/acsmedchemlett.3c00245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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