8TX0
IRAK4 in complex with compound
Summary for 8TX0
Entry DOI | 10.2210/pdb8tx0/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, ~{N}-(1-cyclopropyl-2-oxidanylidene-pyridin-3-yl)-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-7-propan-2-yloxy-imidazo[1,2-a]pyrimidine-6-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70486.14 |
Authors | |
Primary citation | Pfaffenbach, M.,Bolduc, P.N.,Xin, Z.,Gao, F.,Evans, R.,Fang, T.,Chodaparambil, J.V.,Henry, K.L.,Li, P.,Mathieu, S.,Metrick, C.,Vera Rebollar, J.A.,Gu, R.F.,Mccarl, C.A.,Silbereis, J.,Peterson, E.A. Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J.Med.Chem., 67:8383-8395, 2024 Cited by PubMed: 38695469DOI: 10.1021/acs.jmedchem.4c00560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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