8TA0
Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881
Summary for 8TA0
Entry DOI | 10.2210/pdb8ta0/pdb |
Descriptor | Dihydrofolate reductase, 3-[2-(3-{[(6M)-2,4-diamino-6-(3-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | ssgcid, structural genomics, seattle structural genomics center for infectious disease, dihydrofolate reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Mycobacterium ulcerans |
Total number of polymer chains | 1 |
Total formula weight | 20217.50 |
Authors | Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2023-06-26, release date: 2024-08-28) |
Primary citation | Woodward, E.L.,Lovell, S.,Mian, M.R.,Seibold, S. Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM881 To be published, |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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