8ST2
The 3alpha2beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine
Summary for 8ST2
| Entry DOI | 10.2210/pdb8st2/pdb |
| EMDB information | 40752 40753 40754 40755 40756 40757 |
| Descriptor | Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, IgG1 Kappa Light Chain, ... (9 entities in total) |
| Functional Keywords | cys-loop ligand-gated pentameric ion channels, cation-selective channel, acetylcholine, transport protein |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 9 |
| Total formula weight | 386858.92 |
| Authors | Kang, G.,Hibbs, R.E. (deposition date: 2023-05-09, release date: 2024-02-07, Last modification date: 2024-08-21) |
| Primary citation | Mazzaferro, S.,Kang, G.,Natarajan, K.,Hibbs, R.E.,Sine, S.M. Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor. Br.J.Pharmacol., 181:1973-1992, 2024 Cited by PubMed: 38454578DOI: 10.1111/bph.16321 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.94 Å) |
Structure validation
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