8RLN
Crystal structure of human adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with the partial antagonist LUF5834 at the orthosteric pocket
This is a non-PDB format compatible entry.
Summary for 8RLN
Entry DOI | 10.2210/pdb8rln/pdb |
Descriptor | Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, OLEIC ACID, ... (8 entities in total) |
Functional Keywords | gpcr, bril, antagonist, purinergic signaling, cancer immunotherapy, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 52327.53 |
Authors | Strater, N.,Claff, T.,Weisse, R.H.,Muller, C.E. (deposition date: 2024-01-03, release date: 2024-06-19) |
Primary citation | Claff, T.,Mahardhika, A.B.,Vaassen, V.J.,Schlegel, J.G.,Vielmuth, C.,Weisse, R.H.,Strater, N.,Muller, C.E. Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A 2A Receptor. Acs Pharmacol Transl Sci, 7:1415-1425, 2024 Cited by PubMed: 38751633DOI: 10.1021/acsptsci.4c00051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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