8RKE
Crystal structure of the complete N-terminal region of human ZP2 (hZP2-N1N2N3)
This is a non-PDB format compatible entry.
Summary for 8RKE
Entry DOI | 10.2210/pdb8rke/pdb |
Related | 5BUP 5II6 8RKF 8RKG 8RKH |
EMDB information | 19276 19277 |
Descriptor | Zona pellucida sperm-binding protein 2, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | cell adhesion, fertilization, egg-sperm interaction, gamete recognition, sperm receptor, extracellular matrix, egg coat, zona pellucida, glycoprotein, n-glycan, structural protein, zp-n domain, block to polyspermy, post-fertilization cleavage, ovastacin |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 115612.77 |
Authors | Fahrenkamp, D.,de Sanctis, D.,Jovine, L. (deposition date: 2023-12-25, release date: 2024-03-13, Last modification date: 2024-03-27) |
Primary citation | Nishio, S.,Emori, C.,Wiseman, B.,Fahrenkamp, D.,Dioguardi, E.,Zamora-Caballero, S.,Bokhove, M.,Han, L.,Stsiapanava, A.,Algarra, B.,Lu, Y.,Kodani, M.,Bainbridge, R.E.,Komondor, K.M.,Carlson, A.E.,Landreh, M.,de Sanctis, D.,Yasumasu, S.,Ikawa, M.,Jovine, L. ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell, 187:1440-1459.e24, 2024 Cited by PubMed: 38490181DOI: 10.1016/j.cell.2024.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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