8RIV

T2R-TTL-1-K08 complex

This is a non-PDB format compatible entry.

Summary for 8RIV

• Entry DOI: 10.2210/pdb8riv/pdb
• Descriptor: Tubulin alpha-1B chain, (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, IMIDAZOLE, ... (13 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 6
• Total formula weight: 265435.26

Authors

Boiarska, Z.,Homer, J.A.,Steinmetz, M.O.,Moses, J.E.,Prota, A.E.P. (deposition date: 2023-12-19, release date: 2024-03-27)

Primary citation

Homer, J.A.,Koelln, R.A.,Barrow, A.S.,Gialelis, T.L.,Boiarska, Z.,Steinohrt, N.S.,Lee, E.F.,Yang, W.H.,Johnson, R.M.,Chung, T.,Habowski, A.N.,Vishwakarma, D.S.,Bhunia, D.,Avanzi, C.,Moorhouse, A.D.,Jackson, M.,Tuveson, D.A.,Lyons, S.K.,Lukey, M.J.,Fairlie, W.D.,Haider, S.M.,Steinmetz, M.O.,Prota, A.E.,Moses, J.E.
Modular synthesis of functional libraries by accelerated SuFEx click chemistry.
Chem Sci, 15:3879-3892, 2024

PubMed Abstract: Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and exceptional product yields, ASCC streamlines the synthetic workflow, simplifies the purification process, and is ideally suited for discovering functional molecules. We showcase the versatility and practicality of the ASCC reaction as a tool for the late-stage derivatization of bioactive molecules and in the array synthesis of sulfonate-linked, high-potency, microtubule targeting agents (MTAs) that exhibit nanomolar anticancer activity against multidrug-resistant cancer cell lines. These findings underscore ASCC's promise as a robust platform for drug discovery.

PubMed: 38487227
DOI: 10.1039/d3sc05729a

Experimental method

X-RAY DIFFRACTION (2.78 Å)