8R7O
HUWE1 WWE domain in complex with 2'F-ATP
Summary for 8R7O
Entry DOI | 10.2210/pdb8r7o/pdb |
Descriptor | E3 ubiquitin-protein ligase HUWE1, CHLORIDE ION, [[(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-fluoranyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (5 entities in total) |
Functional Keywords | wwe domain, ligase, nucleotide |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 43225.94 |
Authors | |
Primary citation | Munzker, L.,Kimani, S.W.,Fowkes, M.M.,Dong, A.,Zheng, H.,Li, Y.,Dasovich, M.,Zak, K.M.,Leung, A.K.L.,Elkins, J.M.,Kessler, D.,Arrowsmith, C.H.,Halabelian, L.,Bottcher, J. A ligand discovery toolbox for the WWE domain family of human E3 ligases Commun Biol, 7:901-, 2024 Cited by DOI: 10.1038/s42003-024-06584-wPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
Download full validation report