8R74

Galectin-1 in complex with thiogalactoside derivative

Summary for 8R74

Entry DOI	10.2210/pdb8r74/pdb
Descriptor	Galectin-1, (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(2-oxidanyl-1,3-thiazol-4-yl)-1,2,3-triazol-1-yl]oxane-3,5-diol (3 entities in total)
Functional Keywords	galectin, ligand, thiogalactoside derivative, sugar binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	30444.09
Authors	Hakansson, M.,Diehl, C.,Peterson, K.,Zetterberg, F.,Nilsson, U. (deposition date: 2023-11-23, release date: 2024-06-05, Last modification date: 2024-06-19)
Primary citation	Zetterberg, F.R.,Peterson, K.,Nilsson, U.J.,Andreasson Dahlgren, K.,Diehl, C.,Holyer, I.,Hakansson, M.,Khabut, A.,Kahl-Knutson, B.,Leffler, H.,MacKinnon, A.C.,Roper, J.A.,Slack, R.J.,Zarrizi, R.,Pedersen, A. Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. J.Med.Chem., 67:9374-9388, 2024 Cited by PubMed: 38804039 DOI: 10.1021/acs.jmedchem.4c00485 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation