8QJS
VHL/Elongin B/Elongin C complex with compound 155
Summary for 8QJS
Entry DOI | 10.2210/pdb8qjs/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total) |
Functional Keywords | vhl, elongin, vbc, e3 ligase, von hippel-lindau, ubiquitinase, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 12 |
Total formula weight | 168104.16 |
Authors | Kerry, P.S.,Hole, A.J.,Perez-Dorado, J.I. (deposition date: 2023-09-13, release date: 2024-01-17, Last modification date: 2024-02-07) |
Primary citation | Berlin, M.,Cantley, J.,Bookbinder, M.,Bortolon, E.,Broccatelli, F.,Cadelina, G.,Chan, E.W.,Chen, H.,Chen, X.,Cheng, Y.,Cheung, T.K.,Davenport, K.,DiNicola, D.,Gordon, D.,Hamman, B.D.,Harbin, A.,Haskell, R.,He, M.,Hole, A.J.,Januario, T.,Kerry, P.S.,Koenig, S.G.,Li, L.,Merchant, M.,Perez-Dorado, I.,Pizzano, J.,Quinn, C.,Rose, C.M.,Rousseau, E.,Soto, L.,Staben, L.R.,Sun, H.,Tian, Q.,Wang, J.,Wang, W.,Ye, C.S.,Ye, X.,Zhang, P.,Zhou, Y.,Yauch, R.,Dragovich, P.S. PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J.Med.Chem., 67:1262-1313, 2024 Cited by PubMed: 38180485DOI: 10.1021/acs.jmedchem.3c01781 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.191 Å) |
Structure validation
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