8Q2U
Crystal structure of YTHDC1 in complex with Compound 6 (ZA_308)
Summary for 8Q2U
Entry DOI | 10.2210/pdb8q2u/pdb |
Descriptor | YTH domain-containing protein 1, 2-chloranyl-~{N}-methyl-9-(pyridin-4-ylmethyl)purin-6-amine, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ythdc1, inhibitor, complex, reader, rna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 39061.64 |
Authors | Bedi, R.K.,Zalesak, F.,Caflisch, A. (deposition date: 2023-08-03, release date: 2023-12-06, Last modification date: 2024-06-19) |
Primary citation | Zalesak, F.,Nai, F.,Herok, M.,Bochenkova, E.,Bedi, R.K.,Li, Y.,Errani, F.,Caflisch, A. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67:9516-9535, 2024 Cited by PubMed: 38787793DOI: 10.1021/acs.jmedchem.4c00599 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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