8PUY
TEAD2 with a covalent inhibitor
Summary for 8PUY
Entry DOI | 10.2210/pdb8puy/pdb |
Related | 8PUX |
Descriptor | Transcriptional enhancer factor TEF-4, ~{N}-[3-[(3-pentoxyphenyl)amino]phenyl]propanamide, MYRISTIC ACID, ... (4 entities in total) |
Functional Keywords | tead2, inhibitor, covalent, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 55533.00 |
Authors | Guichou, J.F.,Gelin, M.,Allemand, F. (deposition date: 2023-07-17, release date: 2023-12-13, Last modification date: 2024-01-03) |
Primary citation | Fnaiche, A.,Chan, H.C.,Paquin, A.,Gonzalez Suarez, N.,Vu, V.,Li, F.,Allali-Hassani, A.,Cao, M.A.,Szewczyk, M.M.,Bolotokova, A.,Allemand, F.,Gelin, M.,Barsyte-Lovejoy, D.,Santhakumar, V.,Vedadi, M.,Guichou, J.F.,Annabi, B.,Gagnon, A. Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. Acs Med.Chem.Lett., 14:1746-1753, 2023 Cited by PubMed: 38116405DOI: 10.1021/acsmedchemlett.3c00386 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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