8PUY

TEAD2 with a covalent inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE BM30A
Synchrotron site	ESRF
Beamline	BM30A
Temperature [K]	100
Detector technology	PIXEL
Collection date	2023-06-10
Detector	DECTRIS PILATUS 6M-F
Wavelength(s)	0.9697
Spacegroup name	C 1 2 1
Unit cell lengths	122.690, 61.598, 79.699
Unit cell angles	90.00, 117.51, 90.00

Refinement procedure

Resolution	48.380 - 2.200
R-factor	0.22156
Rwork	0.221
R-free	0.25201
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.007
RMSD bond angle	1.406
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHASER
Refinement software	REFMAC (5.8.0267)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	48.380	2.280
High resolution limit [Å]	2.200	2.200
Number of reflections	73715	2617
<I/σ(I)>	12.63
Completeness [%]	96.5
Redundancy	2.8
CC(1/2)	0.997	0.687

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		298	2.8M sodium formate