8PTE

Polyoxidovanadate interaction with proteins: crystal structure of lysozyme bound to octadecavanadate ion (structure B)

Summary for 8PTE

Entry DOI	10.2210/pdb8pte/pdb
Descriptor	Lysozyme C, SODIUM ION, Polyoxidovanadate complex, ... (6 entities in total)
Functional Keywords	protein interaction, vanadium, vanadium acetylacetonate, pov, polyoxo, hydrolase
Biological source	Gallus gallus (chicken)
Total number of polymer chains	1
Total formula weight	16558.94
Authors	Tito, G.,Ferraro, G.,Merlino, A. (deposition date: 2023-07-14, release date: 2024-01-10, Last modification date: 2024-11-06)
Primary citation	Ferraro, G.,Tito, G.,Sciortino, G.,Garribba, E.,Merlino, A. Stabilization and Binding of [V 4 O 12 ] 4- and Unprecedented [V 20 O 54 (NO 3 )] n- to Lysozyme upon Loss of Ligands and Oxidation of the Potential Drug V IV O(acetylacetonato) 2. Angew.Chem.Int.Ed.Engl., 62:e202310655-e202310655, 2023 Cited by PubMed Abstract: High-resolution crystal structures of lysozyme in the presence of the potential drug V O(acetylacetonato) under two different experimental conditions have been solved. The crystallographic study reveals the loss of the ligands, the oxidation of V to V and the subsequent formation of adducts of the protein with two different polyoxidovanadates: [V O ] , which interacts with lysozyme non-covalently, and the unprecedented [V O (NO )] , which is covalenty bound to the side chain of an aspartate residue of symmetry related molecules. PubMed: 37768728 DOI: 10.1002/anie.202310655 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.797 Å)

Structure validation