8PND

The ES3 intermediate of hydroxymethylbilane synthase R167Q variant

Summary for 8PND

• Entry DOI: 10.2210/pdb8pnd/pdb
• Related: 7AAJ 7AAK
• Descriptor: Porphobilinogen deaminase, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, GLYCEROL, ... (5 entities in total)
• Functional Keywords: hydroxymethylbilane synthase, hmbs, porphobilinogen deaminase, pbgd, hydroxymethylbilane, porphobilinogen, haem biosynthesis, porphyria, acute intermittent porphyria, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 82581.81

Authors

Saeter, M.C.,Bustad, H.J.,Laitaoja, M.,Janis, J.,Martinez, A.,Aarsand, A.K.,Kallio, J.P. (deposition date: 2023-06-30, release date: 2023-11-01, Last modification date: 2024-02-14)

• Primary citation: Bustad, H.J.,Christie, M.S.,Laitaoja, M.,Aarsand, A.K.,Martinez, A.,Janis, J.,Kallio, J.P.; One ring closer to a closure: the crystal structure of the ES 3 hydroxymethylbilane synthase intermediate.; Febs J., 291:510-526, 2024; PubMed: 37863644; DOI: 10.1111/febs.16982

Experimental method

X-RAY DIFFRACTION (1.9 Å)