8PND
The ES3 intermediate of hydroxymethylbilane synthase R167Q variant
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Porphobilinogen deaminase | polymer | 364 | 39996.6 | 2 | UniProt (P08397) Pfam (PF01379) Pfam (PF03900) In PDB | Homo sapiens (human) | PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase |
2 | A, B | 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid | non-polymer | 1048.0 | 2 | Chemie (ZWW) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
4 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
5 | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 361 (UniProt: P08397)
PDB | External Database | Details |
---|---|---|
Met -2 | - | initiating methionine |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
Ser 8 | - | expression tag |
Ser 9 | - | expression tag |
Gly 10 | - | expression tag |
Glu 11 | - | expression tag |
Asn 12 | - | expression tag |
Leu 13 | - | expression tag |
Tyr 14 | - | expression tag |
Phe 15 | - | expression tag |
Gln 16 | - | expression tag |
Gly 17 | - | expression tag |
Gln 167 | Arg 167 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79993.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2588.5 | |
All* | Total formula weight | 82581.8 |