8PAS
Crystal structure of MAP4K1 with a SMOL inhibitor
Summary for 8PAS
Entry DOI | 10.2210/pdb8pas/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, 4-[2,6-bis(fluoranyl)-4-(3-morpholin-4-ylpropylcarbamoylamino)phenoxy]-~{N}-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-1~{H}-pyrrolo[2,3-b]pyridine-3-carboxamide (2 entities in total) |
Functional Keywords | kinase, inhibitor, drug discovery, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65866.43 |
Authors | |
Primary citation | Mowat, J.,Carretero, R.,Leder, G.,Aiguabella Font, N.,Neuhaus, R.,Berndt, S.,Guenther, J.,Friberg, A.,Schaefer, M.,Briem, H.,Raschke, M.,Miyatake Ondozabal, H.,Buchmann, B.,Boemer, U.,Hartung, I.,Offringa, R. Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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