8P82
Cryo-EM structure of dimeric UBR5
Summary for 8P82
Entry DOI | 10.2210/pdb8p82/pdb |
EMDB information | 17539 |
Descriptor | E3 ubiquitin-protein ligase UBR5, ZINC ION (2 entities in total) |
Functional Keywords | e3, ubiquitin ligase, hect, ligase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 626919.83 |
Authors | Aguirre, J.D.,Kater, L.,Kempf, G.,Cavadini, S.,Thoma, N.H. (deposition date: 2023-05-31, release date: 2023-06-14, Last modification date: 2024-06-26) |
Primary citation | Tsai, J.M.,Aguirre, J.D.,Li, Y.D.,Brown, J.,Focht, V.,Kater, L.,Kempf, G.,Sandoval, B.,Schmitt, S.,Rutter, J.C.,Galli, P.,Sandate, C.R.,Cutler, J.A.,Zou, C.,Donovan, K.A.,Lumpkin, R.J.,Cavadini, S.,Park, P.M.C.,Sievers, Q.,Hatton, C.,Ener, E.,Regalado, B.D.,Sperling, M.T.,Slabicki, M.,Kim, J.,Zon, R.,Zhang, Z.,Miller, P.G.,Belizaire, R.,Sperling, A.S.,Fischer, E.S.,Irizarry, R.,Armstrong, S.A.,Thoma, N.H.,Ebert, B.L. UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83:2753-2767.e10, 2023 Cited by PubMed: 37478846DOI: 10.1016/j.molcel.2023.06.028 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.36 Å) |
Structure validation
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