8P82

Cryo-EM structure of dimeric UBR5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	E3 ubiquitin-protein ligase UBR5	polymer	2831	313263.7	2	UniProt (O95071) Pfam (PF11547) Pfam (PF00658) Pfam (PF00632) In PDB	Homo sapiens (human)	E3 ubiquitin-protein ligase,HECT domain-containing 1,HECT-type E3 ubiquitin transferase UBR5,Hyperplastic discs protein homolog,hHYD,Progestin-induced protein
2	A, B	ZINC ION	non-polymer		65.4	6	Chemie (ZN)

Sequence modifications

A, B: 1 - 2799 (UniProt: O95071)

PDB	External Database	Details
Met -31	-	initiating methionine
Asp -30	-	expression tag
Tyr -29	-	expression tag
Lys -28	-	expression tag
Asp -27	-	expression tag
Asp -26	-	expression tag
Asp -25	-	expression tag
Asp -24	-	expression tag
Lys -23	-	expression tag
Leu -22	-	expression tag
Ala -21	-	expression tag
Ala -20	-	expression tag
Ala -19	-	expression tag
Asn -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
Ile -15	-	expression tag
Asp -14	-	expression tag
Leu -13	-	expression tag
Ile -12	-	expression tag
Ser -11	-	expression tag
Thr -10	-	expression tag
Ser -9	-	expression tag
Leu -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Lys -5	-	expression tag
Ala -4	-	expression tag
Gly -3	-	expression tag
Phe -2	-	expression tag
Arg -1	-	expression tag
Thr 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	626527.4
Non-Polymers*	Number of molecules	6
	Total formula weight	392.5
All*	Total formula weight	626919.8

*Water molecules are not included.