8P0I

Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor

Summary for 8P0I

• Entry DOI: 10.2210/pdb8p0i/pdb
• Descriptor: Leucyl-cystinyl aminopeptidase, pregnancy serum form, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: insulin regulated aminopeptidase, irap, hsplap, antigen presentation, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 209772.55

Authors

Mpakali, A.,Giastas, P.,Stratikos, E. (deposition date: 2023-05-10, release date: 2024-09-04)

• Primary citation: Mpakali, A.,Georgaki, G.,Buson, A.,Findlay, A.D.,Foot, J.S.,Mauvais, F.X.,van Endert, P.,Giastas, P.,Hamprecht, D.W.,Stratikos, E.; Stabilization of the open conformation omicron f insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor.; Protein Sci., 33:e5151-e5151, 2024; PubMed: 39167040; DOI: 10.1002/pro.5151

Experimental method

X-RAY DIFFRACTION (3.5 Å)