8P0I
Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a small-MW inhibitor
Functional Information from PROSITE/UniProt
| site_id | PS00136 |
| Number of Residues | 11 |
| Details | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. SVVLDDGLvq.D |
| Chain | Residue | Details |
| A | SER336-ASP346 |
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. IIAHELAHQW |
| Chain | Residue | Details |
| A | ILE461-TRP470 |
| site_id | PS01228 |
| Number of Residues | 12 |
| Details | COF_1 Hypothetical cof family signature 1. NLsqDVNGTLVS |
| Chain | Residue | Details |
| A | ASN368-SER379 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095 |
| Chain | Residue | Details |
| A | GLU465 | |
| B | GLU465 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU295 | |
| A | GLY428 | |
| B | GLU295 | |
| B | GLY428 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095 |
| Chain | Residue | Details |
| A | HIS464 | |
| A | HIS468 | |
| A | GLU487 | |
| B | HIS464 | |
| B | HIS468 | |
| B | GLU487 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR549 | |
| B | TYR549 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| A | ASN184 | |
| A | ASN448 | |
| A | ASN682 | |
| A | ASN850 | |
| B | ASN184 | |
| B | ASN448 | |
| B | ASN682 | |
| B | ASN850 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN215 | |
| A | ASN760 | |
| A | ASN834 | |
| A | ASN989 | |
| B | ASN215 | |
| B | ASN256 | |
| B | ASN266 | |
| B | ASN368 | |
| B | ASN374 | |
| B | ASN525 | |
| B | ASN578 | |
| A | ASN256 | |
| B | ASN598 | |
| B | ASN664 | |
| B | ASN760 | |
| B | ASN834 | |
| B | ASN989 | |
| A | ASN266 | |
| A | ASN368 | |
| A | ASN374 | |
| A | ASN525 | |
| A | ASN578 | |
| A | ASN598 | |
| A | ASN664 |
