8ORG
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Summary for 8ORG
Entry DOI | 10.2210/pdb8org/pdb |
EMDB information | 17123 |
Descriptor | Microtubule-associated protein tau (1 entity in total) |
Functional Keywords | amyloid, tau, protein fibril |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 129104.36 |
Authors | Lovestam, S.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-04-13, release date: 2023-04-26, Last modification date: 2024-07-24) |
Primary citation | Tarutani, A.,Lovestam, S.,Zhang, X.,Kotecha, A.,Robinson, A.C.,Mann, D.M.A.,Saito, Y.,Murayama, S.,Tomita, T.,Goedert, M.,Scheres, S.H.W.,Hasegawa, M. Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration. Febs Open Bio, 13:1394-1404, 2023 Cited by PubMed: 37337995DOI: 10.1002/2211-5463.13657 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.3 Å) |
Structure validation
Download full validation report