8OMK

hKHK-C in complex with ADP & fructose 1-phosphate

Summary for 8OMK

Entry DOI	10.2210/pdb8omk/pdb
Descriptor	Ketohexokinase, 1-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	ketohexokinase, khk, product complex, sugar kinase, sugar binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	69459.84
Authors	Ebenhoch, R.,Pautsch, A. (deposition date: 2023-03-31, release date: 2024-01-10, Last modification date: 2024-09-04)
Primary citation	Heine, N.,Weber, A.,Pautsch, A.,Gottschling, D.,Uphues, I.,Bauer, M.,Ebenhoch, R.,Magarkar, A.,Nosse, B.,Kley, J.T. Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability. Bioorg.Med.Chem.Lett., 112:129930-129930, 2024 Cited by PubMed: 39179180 DOI: 10.1016/j.bmcl.2024.129930 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation