8OHR
Crystal structure of human heparanase in complex with glucuronic acid configured 3-geminal diol iminosugar inhibitor
This is a non-PDB format compatible entry.
Summary for 8OHR
Entry DOI | 10.2210/pdb8ohr/pdb |
Descriptor | Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, (3~{S},4~{R})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid, ... (7 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 52228.43 |
Authors | Armstrong, Z.,Yurong, C.,Wu, L.,Overkleeft, H.S.,Davies, G.J. (deposition date: 2023-03-21, release date: 2024-01-10, Last modification date: 2024-01-24) |
Primary citation | Chen, Y.,van den Nieuwendijk, A.M.C.H.,Wu, L.,Moran, E.,Skoulikopoulou, F.,van Riet, V.,Overkleeft, H.S.,Davies, G.J.,Armstrong, Z. Molecular Basis for Inhibition of Heparanases and beta-Glucuronidases by Siastatin B. J.Am.Chem.Soc., 146:125-133, 2024 Cited by PubMed: 38118176DOI: 10.1021/jacs.3c04162 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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