8OHR

Crystal structure of human heparanase in complex with glucuronic acid configured 3-geminal diol iminosugar inhibitor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0016020	cellular_component	membrane
AAA	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:28581485, ECO:0007744|PDB:5E9B

Chain	Residue	Details
AAA	GLU225

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:28581485, ECO:0007744|PDB:5E97, ECO:0007744|PDB:5E98, ECO:0007744|PDB:5E9B

Chain	Residue	Details
AAA	GLU343

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15760902, ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E9C

Chain	Residue	Details
AAA	GLN270

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E9C

Chain	Residue	Details
AAA	HIS296
AAA	ARG303

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E97, ECO:0007744|PDB:5E98, ECO:0007744|PDB:5E9B

Chain	Residue	Details
AAA	TYR348
AAA	GLY389

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14573609, ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E8M, ECO:0007744|PDB:5E97

Chain	Residue	Details
AAA	ASN162

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14573609

Chain	Residue	Details
AAA	ASN178

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14573609, ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E8M, ECO:0007744|PDB:5E97, ECO:0007744|PDB:5E98, ECO:0007744|PDB:5E9B, ECO:0007744|PDB:5E9C

Chain	Residue	Details
AAA	ASN200
AAA	ASN459

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14573609, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E8M

Chain	Residue	Details
AAA	ASN217

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14573609, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:28581485, ECO:0007744|PDB:5E8M, ECO:0007744|PDB:5E97, ECO:0007744|PDB:5E98, ECO:0007744|PDB:5E9B, ECO:0007744|PDB:5E9C

Chain	Residue	Details
AAA	ASN238

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