8K9X
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 5 (ADKI5)
Summary for 8K9X
Entry DOI | 10.2210/pdb8k9x/pdb |
Descriptor | Lysine--tRNA ligase, (2~{S})-2,6-bis(azanyl)-~{N}-[3-[2-[[4-[(2,5-dimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]phenyl]sulfonylpropyl]hexanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | lysyl-trna synthetase, ligase |
Biological source | Plasmodium falciparum CAMP/Malaysia |
Total number of polymer chains | 2 |
Total formula weight | 121098.10 |
Authors | |
Primary citation | Zhou, J.,Xia, M.,Huang, Z.,Qiao, H.,Yang, G.,Qian, Y.,Li, P.,Zhang, Z.,Gao, X.,Jiang, L.,Wang, J.,Li, W.,Fang, P. Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7:742-742, 2024 Cited by PubMed: 38890421DOI: 10.1038/s42003-024-06455-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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