8K9X
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 5 (ADKI5)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Lysine--tRNA ligase | polymer | 516 | 59781.1 | 2 | UniProt (A0A024X378) Pfam (PF01336) Pfam (PF00152) In PDB | Plasmodium falciparum CAMP/Malaysia | Lysyl-tRNA synthetase |
2 | A, B | (2~{S})-2,6-bis(azanyl)-~{N}-[3-[2-[[4-[(2,5-dimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]phenyl]sulfonylpropyl]hexanamide | non-polymer | 572.7 | 2 | Chemie (JUA) | |||
3 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
4 | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 77 - 583 (UniProt: A0A024X378)
PDB | External Database | Details |
---|---|---|
Met 76 | - | initiating methionine |
Gly 584 | - | expression tag |
Gly 585 | - | expression tag |
His 586 | - | expression tag |
His 587 | - | expression tag |
His 588 | - | expression tag |
His 589 | - | expression tag |
His 590 | - | expression tag |
His 591 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 119562.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1535.8 | |
All* | Total formula weight | 121098.1 |