8K4F
DHODH in complex with compound A0
Summary for 8K4F
Entry DOI | 10.2210/pdb8k4f/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, SULFATE ION, TETRAETHYLENE GLYCOL, ... (9 entities in total) |
Functional Keywords | inhibitor, complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41711.94 |
Authors | |
Primary citation | Zhou, X.,Gou, K.,Xu, J.,Jian, L.,Luo, Y.,Li, C.,Guan, X.,Qiu, J.,Zou, J.,Zhang, Y.,Zhong, X.,Zeng, T.,Zhou, Y.,Xiao, Y.,Yang, X.,Chen, W.,Gao, P.,Liu, C.,Zhou, Y.,Tao, L.,Liu, X.,Cen, X.,Chen, Q.,Sun, Q.,Luo, Y.,Zhao, Y. Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66:14755-14786, 2023 Cited by PubMed: 37870434DOI: 10.1021/acs.jmedchem.3c01365 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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