8JUB
Crystal structure of glutaminase C in complex with compound 27
Summary for 8JUB
Entry DOI | 10.2210/pdb8jub/pdb |
Descriptor | Glutaminase kidney isoform, mitochondrial, 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid (3 entities in total) |
Functional Keywords | inhibitor, complex, antitumor protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 235974.36 |
Authors | Wang, X.,Hanyu, S.,Tingting, D. (deposition date: 2023-06-26, release date: 2023-10-11, Last modification date: 2023-11-01) |
Primary citation | Sun, H.,Du, T.,Yang, M.,Liu, X.,Xue, X.,Chen, K.,Lang, X.,Chen, X.,Wang, B.,Wang, X. Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14:1455-1466, 2023 Cited by PubMed: 37849538DOI: 10.1021/acsmedchemlett.3c00375 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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