8JUB
Crystal structure of glutaminase C in complex with compound 27
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutaminase kidney isoform, mitochondrial | polymer | 533 | 58780.9 | 4 | UniProt (O94925) Pfam (PF17959) Pfam (PF04960) | Homo sapiens (human) | GLS,K-glutaminase,L-glutamine amidohydrolase |
| 2 | E, F (A, D) | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid | non-polymer | 425.5 | 2 | Chemie (V4I) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 387 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 71 - 595 (UniProt: O94925)
| PDB | External Database | Details |
|---|---|---|
| Met 63 | - | initiating methionine |
| Gly 64 | - | expression tag |
| His 65 | - | expression tag |
| His 66 | - | expression tag |
| His 67 | - | expression tag |
| His 68 | - | expression tag |
| His 69 | - | expression tag |
| His 70 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235123.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 850.9 | |
| All* | Total formula weight | 235974.4 |
