8JIZ

Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation

Summary for 8JIZ

• Entry DOI: 10.2210/pdb8jiz/pdb
• EMDB information: 36335
• Descriptor: Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, Fab5F6 Heavy Chain, ... (6 entities in total)
• Functional Keywords: nmdar, autoimmune encephalitis, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 489768.21

Authors

Wang, H.,Zhu, S. (deposition date: 2023-05-29, release date: 2024-06-05, Last modification date: 2024-09-11)

• Primary citation: Wang, H.,Xie, C.,Deng, B.,Ding, J.,Li, N.,Kou, Z.,Jin, M.,He, J.,Wang, Q.,Wen, H.,Zhang, J.,Zhou, Q.,Chen, S.,Chen, X.,Yuan, T.F.,Zhu, S.; Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis.; Nat.Struct.Mol.Biol., 2024; PubMed: 39227720; DOI: 10.1038/s41594-024-01387-3

Experimental method

ELECTRON MICROSCOPY (3.8 Å)