8JIZ

Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Glutamate receptor ionotropic, NMDA 2A	polymer	841	94136.0	2	UniProt (Q12879) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (human)	GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NMDAR2A,NR2A,hNR2A
2	B, D (B, D)	Glutamate receptor ionotropic, NMDA 1	polymer	847	95236.1	2	UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (human)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
3	E, G (E, G)	Fab5F6 Heavy Chain	polymer	259	27654.1	2		Homo sapiens
4	F, H (F, H)	Fab5F6 Light Chain	polymer	236	25912.1	2		Homo sapiens
5	I, J, K, L, M (I, J, K, L, M)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
6	N, O, P, Q, R... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	485876.5
Branched	Number of molecules	5
	Total formula weight	2122.0
Non-Polymers*	Number of molecules	8
	Total formula weight	1769.7
All*	Total formula weight	489768.2

*Water molecules are not included.