8IV4

Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 3E2 (local refinement)

Summary for 8IV4

Entry DOI	10.2210/pdb8iv4/pdb
EMDB information	35740
Descriptor	light chain of 3E2, heavy chain of 3E2, light chain of 8H12, ... (6 entities in total)
Functional Keywords	sars-cov-2, neutralizing antibody, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	5
Total formula weight	72850.50
Authors	Sun, H.,Jiang, Y.,Zheng, Q.,Li, S.,Xia, N. (deposition date: 2023-03-26, release date: 2023-08-16, Last modification date: 2024-02-14)
Primary citation	Sun, H.,Deng, T.,Zhang, Y.,Lin, Y.,Jiang, Y.,Jiang, Y.,Huang, Y.,Song, S.,Cui, L.,Li, T.,Xiong, H.,Lan, M.,Liu, L.,Li, Y.,Fang, Q.,Yu, K.,Jiang, W.,Zhou, L.,Que, Y.,Zhang, T.,Yuan, Q.,Cheng, T.,Zhang, Z.,Yu, H.,Zhang, J.,Luo, W.,Li, S.,Zheng, Q.,Gu, Y.,Xia, N. Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD. Protein Cell, 15:121-134, 2024 Cited by PubMed: 37470320 DOI: 10.1093/procel/pwad040 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.59 Å)

Structure validation