8I71
Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM)
Summary for 8I71
Entry DOI | 10.2210/pdb8i71/pdb |
Descriptor | Capsid protein, CHLORIDE ION, ISOPROPYL ALCOHOL, ... (7 entities in total) |
Functional Keywords | capsid assembly inhibitor, antiviral protein, viral protein |
Biological source | Hepatitis B virus subtype adyw |
Total number of polymer chains | 6 |
Total formula weight | 109678.26 |
Authors | |
Primary citation | Zhang, W.,Guo, L.,Liu, H.,Wu, G.,Shi, H.,Zhou, M.,Zhang, Z.,Kou, B.,Hu, T.,Zhou, Z.,Xu, Z.,Zhou, X.,Zhou, Y.,Tian, X.,Yang, G.,Young, J.A.T.,Qiu, H.,Ottaviani, G.,Xie, J.,Mayweg, A.V.,Shen, H.C.,Zhu, W. Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection. J.Med.Chem., 66:4253-4270, 2023 Cited by PubMed: 36896968DOI: 10.1021/acs.jmedchem.3c00173 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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