8I4S
the complex structure of SARS-CoV-2 Mpro with D8
Summary for 8I4S
Entry DOI | 10.2210/pdb8i4s/pdb |
Descriptor | ORF1a polyprotein, 3-(4-fluoranyl-3-methyl-phenyl)-2-(2-methylpropyl)-5,6,7-tris(oxidanyl)quinazolin-4-one (3 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 1 |
Total formula weight | 37461.45 |
Authors | |
Primary citation | Zhang, K.,Wang, T.,Li, M.,Liu, M.,Tang, H.,Wang, L.,Ye, K.,Yang, J.,Jiang, S.,Xiao, Y.,Xie, Y.,Lu, M.,Zhang, X. Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 M pro ). Eur.J.Med.Chem., 257:115487-115487, 2023 Cited by PubMed: 37257212DOI: 10.1016/j.ejmech.2023.115487 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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