8HTT

Cryo-EM structure of human TMEM87A, gluconate-bound

Summary for 8HTT

• Entry DOI: 10.2210/pdb8htt/pdb
• Related: 8HSI
• EMDB information: 35017
• Descriptor: Transmembrane protein 87A,EGFP, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: non-selective cation channel, ion channel, membrane protein, golgi-localized protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 99597.12

Authors

Han, A.,Kim, H.M. (deposition date: 2022-12-21, release date: 2023-12-27, Last modification date: 2024-09-18)

• Primary citation: Kang, H.,Han, A.R.,Zhang, A.,Jeong, H.,Koh, W.,Lee, J.M.,Lee, H.,Jo, H.Y.,Maria-Solano, M.A.,Bhalla, M.,Kwon, J.,Roh, W.S.,Yang, J.,An, H.J.,Choi, S.,Kim, H.M.,Lee, C.J.; GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory.; Nat Commun, 15:5830-5830, 2024; PubMed: 38992057; DOI: 10.1038/s41467-024-49297-8

Experimental method

ELECTRON MICROSCOPY (3.6 Å)