8HTB
Staphylococcus aureus FtsZ 12-316 complexed with TXH9179
Summary for 8HTB
Entry DOI | 10.2210/pdb8htb/pdb |
Descriptor | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | gtpase, protein-inhibitor complex, antibacterial agent, hydrolase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 32681.63 |
Authors | Bryan, E.,Ferrer-Gonzalez, E.,Sagong, H.Y.,Fujita, J.,Mark, L.,Kaul, M.,LaVoie, E.J.,Matsumura, H.,Pilch, D.S. (deposition date: 2022-12-21, release date: 2023-09-20) |
Primary citation | Bryan, E.,Ferrer-Gonzalez, E.,Sagong, H.Y.,Fujita, J.,Mark, L.,Kaul, M.,LaVoie, E.J.,Matsumura, H.,Pilch, D.S. Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus. Acs Chem.Biol., 18:629-642, 2023 Cited by PubMed: 36854145DOI: 10.1021/acschembio.2c00934 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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