8HMA
Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET)
This is a non-PDB format compatible entry.
Summary for 8HMA
Entry DOI | 10.2210/pdb8hma/pdb |
EMDB information | 34891 |
Descriptor | Voltage-dependent L-type calcium channel subunit alpha, Isoform 2c of Voltage-dependent L-type calcium channel subunit beta-2, Voltage-dependent calcium channel subunit alpha-2/delta-1, ... (9 entities in total) |
Functional Keywords | tet bound state, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 441882.08 |
Authors | |
Primary citation | Wei, Y.,Yu, Z.,Wang, L.,Li, X.,Li, N.,Bai, Q.,Wang, Y.,Li, R.,Meng, Y.,Xu, H.,Wang, X.,Dong, Y.,Huang, Z.,Zhang, X.C.,Zhao, Y. Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15:2772-2772, 2024 Cited by PubMed: 38555290DOI: 10.1038/s41467-024-47116-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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