8HMA
Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Voltage-dependent L-type calcium channel subunit alpha | polymer | 2173 | 243947.0 | 1 | UniProt (A0A0A0MSA1) Pfam (PF00520) Pfam (PF16905) Pfam (PF08763) Pfam (PF16885) UniProt (by SIFTS) (Q13936) | Homo sapiens (human) | |
| 2 | B (H) | Isoform 2c of Voltage-dependent L-type calcium channel subunit beta-2 | polymer | 632 | 70952.7 | 1 | UniProt (Q08289) Pfam (PF12052) Pfam (PF00625) | Homo sapiens (human) | CAB2,Calcium channel voltage-dependent subunit beta 2,Lambert-Eaton myasthenic syndrome antigen B,MYSB |
| 3 | C (F) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1071 | 121197.4 | 1 | UniProt (P54289) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Homo sapiens (human) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 4 | D (E) | HEXADECANE | non-polymer | 226.4 | 1 | Chemie (R16) | |||
| 5 | E, F, H (E) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 3 | Chemie (3PE) | |||
| 6 | G (E) | 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman | non-polymer | 620.7 | 1 | Chemie (A1AC9) | |||
| 7 | I, J (E) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | K, L, M, N, P... (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) | |||
| 9 | O (F) | beta-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (BMA) |
Sequence modifications
E: 1 - 2221 (UniProt: A0A0A0MSA1)
| PDB | External Database | Details |
|---|---|---|
| Val 372 | Met 372 | conflict |
| Asn 373 | Gln 373 | conflict |
| Val 376 | Met 376 | conflict |
| Arg 378 | Tyr 378 | conflict |
| Asp 379 | Glu 379 | conflict |
| Trp 380 | Leu 380 | conflict |
| Ile 383 | Val 383 | conflict |
| Thr 387 | Ser 387 | conflict |
| Ile 389 | Val 389 | conflict |
| Ile 391 | Phe 391 | conflict |
| Leu 966 | Ile 946 | conflict |
| Ile 969 | Ala 949 | conflict |
| Val 1351 | Thr 1303 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 436097.1 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 5785.0 | |
| All* | Total formula weight | 441882.1 |
