8GK7

MsbA bound to cerastecin C

Summary for 8GK7

• Entry DOI: 10.2210/pdb8gk7/pdb
• EMDB information: 40180
• Descriptor: Lipid A export ATP-binding/permease protein MsbA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 2-[(4-butylbenzene-1-sulfonyl)amino]-5-[(3-{4-[(4-butylbenzene-1-sulfonyl)amino]-3-carboxyanilino}-3-oxopropyl)carbamoyl]benzoic acid (3 entities in total)
• Functional Keywords: msba, antibacterial, inhibitor, cerastecin, antimicrobial protein
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 2
• Total formula weight: 135578.44

Authors

Chen, Y.,Klein, D. (deposition date: 2023-03-17, release date: 2024-04-24, Last modification date: 2024-05-22)

• Primary citation: Wang, H.,Ishchenko, A.,Skudlarek, J.,Shen, P.,Dzhekieva, L.,Painter, R.E.,Chen, Y.T.,Bukhtiyarova, M.,Leithead, A.,Tracy, R.,Babaoglu, K.,Bahnck-Teets, C.,Buevich, A.,Cabalu, T.D.,Labroli, M.,Lange, H.,Lei, Y.,Li, W.,Liu, J.,Mann, P.A.,Meng, T.,Mitchell, H.J.,Mulhearn, J.,Scapin, G.,Sha, D.,Shaw, A.W.,Si, Q.,Tong, L.,Wu, C.,Wu, Z.,Xiao, J.C.,Xu, M.,Zhang, L.K.,McKenney, D.,Miller, R.R.,Black, T.A.,Cooke, A.,Balibar, C.J.,Klein, D.J.,Raheem, I.,Walker, S.S.; Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.; Nat Microbiol, 9:1244-1255, 2024; PubMed: 38649414; DOI: 10.1038/s41564-024-01667-0

Experimental method

ELECTRON MICROSCOPY (3.32 Å)