8GDM
Crystal structure of human cellular retinol binding protein 1 in complex with {[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl}(methyl)[1-(thiophen-2-yl)ethyl]amine
Summary for 8GDM
Entry DOI | 10.2210/pdb8gdm/pdb |
Related | 8GD2 |
Descriptor | Retinol-binding protein 1, (1S)-N-{[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl}-N-methyl-1-(thiophen-2-yl)ethan-1-amine (3 entities in total) |
Functional Keywords | rbp1, crbp1, retinol-binding, retinol, vitamin a, retinol-binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 17089.58 |
Authors | Plau, J.,Golczak, M. (deposition date: 2023-03-06, release date: 2023-10-04, Last modification date: 2023-11-01) |
Primary citation | Plau, J.,Morgan, C.E.,Fedorov, Y.,Banerjee, S.,Adams, D.J.,Blaner, W.S.,Yu, E.W.,Golczak, M. Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18:2309-2323, 2023 Cited by PubMed: 37713257DOI: 10.1021/acschembio.3c00402 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report