8GD9
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Summary for 8GD9
Entry DOI | 10.2210/pdb8gd9/pdb |
EMDB information | 29943 29944 29945 29946 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein subunit gamma, ... (6 entities in total) |
Functional Keywords | gpcr complex, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 148167.50 |
Authors | Shenming, H.,Mengyao, X.,Lei, L.,Yang, D.,Sheng, C.,Jinpeng, S. (deposition date: 2023-03-03, release date: 2024-01-10) |
Primary citation | Huang, S.M.,Xiong, M.Y.,Liu, L.,Mu, J.,Wang, M.W.,Jia, Y.L.,Cai, K.,Tie, L.,Zhang, C.,Cao, S.,Wen, X.,Wang, J.L.,Guo, S.C.,Li, Y.,Qu, C.X.,He, Q.T.,Cai, B.Y.,Xue, C.,Gan, S.,Xie, Y.,Cong, X.,Yang, Z.,Kong, W.,Li, S.,Li, Z.,Xiao, P.,Yang, F.,Yu, X.,Guan, Y.F.,Zhang, X.,Liu, Z.,Yang, B.X.,Du, Y.,Sun, J.P. Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120:e2216329120-e2216329120, 2023 Cited by PubMed: 37478163DOI: 10.1073/pnas.2216329120 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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