8GD7
Loop Deleted DNA Polymerase Theta Polymerase Domain in Complex with Double Strand DNA Overhang and Inhibitor
Summary for 8GD7
Entry DOI | 10.2210/pdb8gd7/pdb |
Descriptor | DNA polymerase theta, DNA Template, DNA Primer, ... (6 entities in total) |
Functional Keywords | dna polymerase theta, inhibitor, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 85224.14 |
Authors | |
Primary citation | Fried, W.,Tyagi, M.,Minakhin, L.,Chandramouly, G.,Tredinnick, T.,Ramanjulu, M.,Auerbacher, W.,Calbert, M.,Rusanov, T.,Hoang, T.,Borisonnik, N.,Betsch, R.,Krais, J.J.,Wang, Y.,Vekariya, U.M.,Gordon, J.,Morton, G.,Kent, T.,Skorski, T.,Johnson, N.,Childers, W.,Chen, X.S.,Pomerantz, R.T. Discovery of a small-molecule inhibitor that traps Pol theta on DNA and synergizes with PARP inhibitors. Nat Commun, 15:2862-2862, 2024 Cited by PubMed: 38580648DOI: 10.1038/s41467-024-46593-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.24 Å) |
Structure validation
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