8GD4
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6
Summary for 8GD4
Entry DOI | 10.2210/pdb8gd4/pdb |
Descriptor | Hdac6 protein, 2-(benzylamino)-N'-(difluoroacetyl)pyrimidine-5-carbohydrazide, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase, histone deacetylase, inhibitor, metallohydrolase |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 81500.74 |
Authors | Watson, P.R.,Craigin, A.D.,Christianson, D.W. (deposition date: 2023-03-03, release date: 2023-10-04, Last modification date: 2023-10-25) |
Primary citation | Konig, B.,Watson, P.R.,Ressing, N.,Cragin, A.D.,Schaker-Hubner, L.,Christianson, D.W.,Hansen, F.K. Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 . J.Med.Chem., 66:13821-13837, 2023 Cited by PubMed: 37782298DOI: 10.1021/acs.jmedchem.3c01345 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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