8G9Q
Tricomplex of Compound-1, KRAS G12C, and CypA
Summary for 8G9Q
Entry DOI | 10.2210/pdb8g9q/pdb |
Descriptor | GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, small gtpase, cancer, tricomplex, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 38654.61 |
Authors | Tomlinson, A.C.A.,Chen, A.,Knox, J.E.,Yano, J.K. (deposition date: 2023-02-21, release date: 2023-08-16, Last modification date: 2023-08-30) |
Primary citation | Schulze, C.J.,Seamon, K.J.,Zhao, Y.,Yang, Y.C.,Cregg, J.,Kim, D.,Tomlinson, A.,Choy, T.J.,Wang, Z.,Sang, B.,Pourfarjam, Y.,Lucas, J.,Cuevas-Navarro, A.,Ayala-Santos, C.,Vides, A.,Li, C.,Marquez, A.,Zhong, M.,Vemulapalli, V.,Weller, C.,Gould, A.,Whalen, D.M.,Salvador, A.,Milin, A.,Saldajeno-Concar, M.,Dinglasan, N.,Chen, A.,Evans, J.,Knox, J.E.,Koltun, E.S.,Singh, M.,Nichols, R.,Wildes, D.,Gill, A.L.,Smith, J.A.M.,Lito, P. Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science, 381:794-799, 2023 Cited by PubMed: 37590355DOI: 10.1126/science.adg9652 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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