8G2E
PKM2 bound to compound 2
Summary for 8G2E
Entry DOI | 10.2210/pdb8g2e/pdb |
Descriptor | Pyruvate kinase PKM, 3-[(3-aminophenyl)methyl]-5-methyl-7-[methyl(oxidanyl)-$l^{3}-sulfanyl]pyridazino[4,5-b]indol-4-one, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | activator, small molecule, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 61698.69 |
Authors | Stuckey, J.A. (deposition date: 2023-02-03, release date: 2023-05-17, Last modification date: 2024-05-22) |
Primary citation | Wubben, T.J.,Chaudhury, S.,Watch, B.T.,Stuckey, J.A.,Weh, E.,Fernando, R.,Goswami, M.,Pawar, M.,Rech, J.C.,Besirli, C.G. Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis. Pharmaceuticals, 16:-, 2023 Cited by PubMed: 37242488DOI: 10.3390/ph16050705 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.838 Å) |
Structure validation
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